Clinical Efficacy of a Single Injection of Ceftiofur Crystalline Free Acid Sterile Injectable Suspension versus Three Daily Injections of Ceftiofur Sodium Sterile Powder for the Treatment of Footrot in Feedlot Cattle*
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چکیده
A study was conducted in a feedlot in Alberta, Canada, to compare the clinical efficacy of a single injection of ceftiofur crystalline free acid sterile injectable suspension with three daily treatments of ceftiofur sodium sterile powder for the treatment of footrot. Use of a long-acting antimicrobial to treat footrot would reduce labor costs and hospital pen space requirements during high-risk periods. Four hundred cattle clinically diagnosed with footrot were systematically randomized to one of two treatment groups. The treatment success rate at 14 days after treatment (99.5% for ceftiofur crystalline free acid sterile injectable suspension and 99.0% for ceftiofur sodium sterile powder for injection) was not statistically different (P > .05) between the two drugs.
منابع مشابه
A comprehensive review of ceftiofur sodium and hydrochloride formulations for treatment of acute bovine foot rot.
Seven well-controlled studies conducted under multiple management conditions demonstrated that ceftiofur, a late-generation veterinary parenteral cephalosporin, is effective for the treatment of bovine foot rot in beef and dairy cattle. Two preliminary dosage titration studies using a challenge model compared the efficacy of ceftiofur (1.1 mg or 2.2 mg ceftiofur equivalents [CE]/kg administered...
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• EXCEDE (ceftiofur crystalline free acid) Sterile Suspension controlled bovine respiratory disease (BRD) for up to nine days after administration in a challenge model. • EXCEDE was superior to Micotil (tilmicosin) 300 Injection for lung lesion scores, respiratory scores, and rectal temperature. • Concentrations of ceftiofur and related metabolites were above the efficacy threshold for BRD path...
متن کاملPart 522—implantation or Injectable Dosage Form New Animal Drugs
§ 522.313a Ceftiofur crystalline free acid. * * * * * (e) * * * (2) * * * (i) Amount. For subcutaneous (SC) injection in the posterior aspect of the ear where it attaches to the head (base of the ear) in lactating dairy cattle. For SC injection in the middle third of the posterior aspect of the ear or in the base of the ear in beef and non-lactating dairy cattle. (A) Single-dose regimen: 6.6 mg...
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• Concentrations of ceftiofur and related metabolites in interstitial fluid* serve as a better indicator of target-site drug concentrations than do plasma concentrations. • Plasma and infected chamber interstitial fluid concentrations of ceftiofur and related metabolites were above the efficacy threshold** 9 days after subcutaneous administration of EXCEDE (ceftiofur crystalline free acid) Ster...
متن کاملDuration of efficacy of ceftiofur crystalline free acid sterile suspension against clinical disease in grower pigs challenged with <i>Actinobacillus pleuropneumoniae</i>
Materials and methods: One hundred and ninety male piglets were blocked by weight and randomly assigned to 19 pens of 10 animals each, with three pens randomly assigned to each of six treatments. Pigs were challenged with A pleuropneumoniae at 7 to 8 weeks old (Day 0). Groups 1 through 5 were treated with a single intramuscular dose of CCFA-SS (5 mg ceftiofur equivalents per kg body weight) on ...
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تاریخ انتشار 2008